BDBM50131229 CHEMBL3634773::US9260425, 368

SMILES: C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1

InChI Key: InChIKey=BDYUVBLOKBRWER-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50131229 (CHEMBL3634773 | US9260425, 368) Show SMILES C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1 Show InChI InChI=1S/C18H18N8/c1-2-14(22-16(3-1)25-7-4-19-5-8-25)18-13-10-17(26-9-6-20-12-26)21-11-15(13)23-24-18/h1-3,6,9-12,19H,4-5,7-8H2,(H,23,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50131229 (CHEMBL3634773 | US9260425, 368) Show SMILES C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1 Show InChI InChI=1S/C18H18N8/c1-2-14(22-16(3-1)25-7-4-19-5-8-25)18-13-10-17(26-9-6-20-12-26)21-11-15(13)23-24-18/h1-3,6,9-12,19H,4-5,7-8H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50131229 (CHEMBL3634773 | US9260425, 368) Show SMILES C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1 Show InChI InChI=1S/C18H18N8/c1-2-14(22-16(3-1)25-7-4-19-5-8-25)18-13-10-17(26-9-6-20-12-26)21-11-15(13)23-24-18/h1-3,6,9-12,19H,4-5,7-8H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.82	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genetech, Inc. US Patent					Assay Description PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....				US Patent US9260425 (2016) BindingDB Entry DOI: 10.7270/Q2RR1X3X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50131229 (CHEMBL3634773 | US9260425, 368) Show SMILES C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1 Show InChI InChI=1S/C18H18N8/c1-2-14(22-16(3-1)25-7-4-19-5-8-25)18-13-10-17(26-9-6-20-12-26)21-11-15(13)23-24-18/h1-3,6,9-12,19H,4-5,7-8H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair