null

SMILES: Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(O[C@@H]2CCCNC2)n1

InChI Key: InChIKey=XJYVGYJMUZECDN-CQSZACIVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50131263 (CHEMBL3634755 | US9260425, 264) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(O[C@@H]2CCCNC2)n1 |r| Show InChI InChI=1S/C20H21N7O/c1-27-12-13(9-23-27)17-8-15-18(11-22-17)25-26-20(15)16-5-2-6-19(24-16)28-14-4-3-7-21-10-14/h2,5-6,8-9,11-12,14,21H,3-4,7,10H2,1H3,(H,25,26)/t14-/m1/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) Article DOI: 10.1016/j.bmcl.2015.09.052 BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50131263 (CHEMBL3634755 | US9260425, 264) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(O[C@@H]2CCCNC2)n1 |r| Show InChI InChI=1S/C20H21N7O/c1-27-12-13(9-23-27)17-8-15-18(11-22-17)25-26-20(15)16-5-2-6-19(24-16)28-14-4-3-7-21-10-14/h2,5-6,8-9,11-12,14,21H,3-4,7,10H2,1H3,(H,25,26)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	0.270	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genetech, Inc. US Patent					Assay Description PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....				US Patent US9260425 (2016) BindingDB Entry DOI: 10.7270/Q2RR1X3X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50131263 (CHEMBL3634755 | US9260425, 264) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(O[C@@H]2CCCNC2)n1 |r| Show InChI InChI=1S/C20H21N7O/c1-27-12-13(9-23-27)17-8-15-18(11-22-17)25-26-20(15)16-5-2-6-19(24-16)28-14-4-3-7-21-10-14/h2,5-6,8-9,11-12,14,21H,3-4,7,10H2,1H3,(H,25,26)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) Article DOI: 10.1016/j.bmcl.2015.09.052 BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50131263 (CHEMBL3634755 | US9260425, 264) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(O[C@@H]2CCCNC2)n1 |r| Show InChI InChI=1S/C20H21N7O/c1-27-12-13(9-23-27)17-8-15-18(11-22-17)25-26-20(15)16-5-2-6-19(24-16)28-14-4-3-7-21-10-14/h2,5-6,8-9,11-12,14,21H,3-4,7,10H2,1H3,(H,25,26)/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	6.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins				Bioorg Med Chem Lett 25: 5258-64 (2015) Article DOI: 10.1016/j.bmcl.2015.09.052 BindingDB Entry DOI: 10.7270/Q2TT4SR7
					More data for this Ligand-Target Pair