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BDBM50132222 4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL102911

SMILES: CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI Key: InChIKey=YDVWNTXBGIEREW-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50132222   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132222
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-18-24-23(17-25(26)35-2)27(30-19-29-24)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
BindingDB Entry DOI: 10.7270/Q2X929PJ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132222
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-18-24-23(17-25(26)35-2)27(30-19-29-24)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 0.0100n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair