Found 6 hits for monomerid = 50132308 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C alpha |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |
PKC alpha and beta-2
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C beta 2 |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |
PKC alpha and beta-2
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISA |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |
Protein kinase C, gamma
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C gamma |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |
PKC alpha and beta-2
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C beta 1 |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50132308
(20-(2-hydroxyethyl)-17,23-dioxa-4,14,20,26-tetraaz...)Show SMILES OCCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21 |t:12| Show InChI InChI=1S/C30H32N4O5/c35-14-9-32-10-15-38-17-12-33-19-23(21-5-1-3-7-25(21)33)27-28(30(37)31-29(27)36)24-20-34(13-18-39-16-11-32)26-8-4-2-6-22(24)26/h1-8,19-20,35H,9-18H2,(H,31,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of Glycogen synthase kinase-3 beta |
Bioorg Med Chem Lett 13: 3049-53 (2003)
BindingDB Entry DOI: 10.7270/Q2DR2TVT |
More data for this Ligand-Target Pair | |