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BDBM50132440 2-(5-methoxy-3-((2-oxo-5-sulfamoylindolin-3-ylidene)methyl)-1H-indol-1-yl)acetic acid::CHEMBL1788130::CHEMBL420100::{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indol-(3Z)-ylidenemethyl]-indol-1-yl}-acetic acid; piperidine salt

SMILES: COc1ccc2n(CC(O)=O)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1

InChI Key: InChIKey=CEJLEKMBODOQHB-SOFYXZRVSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50132440   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50132440
PNG
(2-(5-methoxy-3-((2-oxo-5-sulfamoylindolin-3-yliden...)
Show SMILES COc1ccc2n(CC(O)=O)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
Show InChI InChI=1S/C20H17N3O6S/c1-29-12-2-5-18-14(7-12)11(9-23(18)10-19(24)25)6-16-15-8-13(30(21,27)28)3-4-17(15)22-20(16)26/h2-9H,10H2,1H3,(H,22,26)(H,24,25)(H2,21,27,28)/b16-6-
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PC cid
PC sid
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n/an/a 850n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis


Bioorg Med Chem Lett 13: 3111-4 (2003)


BindingDB Entry DOI: 10.7270/Q2ZG6SS7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50132440
PNG
(2-(5-methoxy-3-((2-oxo-5-sulfamoylindolin-3-yliden...)
Show SMILES COc1ccc2n(CC(O)=O)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
Show InChI InChI=1S/C20H17N3O6S/c1-29-12-2-5-18-14(7-12)11(9-23(18)10-19(24)25)6-16-15-8-13(30(21,27)28)3-4-17(15)22-20(16)26/h2-9H,10H2,1H3,(H,22,26)(H,24,25)(H2,21,27,28)/b16-6-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair