BDBM50132444 5-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indol-(3Z)-ylidenemethyl]-indol-1-yl}-pentanoic acid ethyl ester::CHEMBL104651::ethyl 5-(5-methoxy-3-((2-oxo-5-sulfamoylindolin-3-ylidene)methyl)-1H-indol-1-yl)pentanoate

SMILES: CCOC(=O)CCCCn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2cc(OC)ccc12

InChI Key: InChIKey=XHTDZDXBNPQPFB-MTJSOVHGSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50132444 (5-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...) Show SMILES CCOC(=O)CCCCn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2cc(OC)ccc12 Show InChI InChI=1S/C25H27N3O6S/c1-3-34-24(29)6-4-5-11-28-15-16(19-13-17(33-2)7-10-23(19)28)12-21-20-14-18(35(26,31)32)8-9-22(20)27-25(21)30/h7-10,12-15H,3-6,11H2,1-2H3,(H,27,30)(H2,26,31,32)/b21-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	678	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair
Immunoglobulin epsilon Fc receptor (Homo sapiens (Human))	BDBM50132444 (5-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...) Show SMILES CCOC(=O)CCCCn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2cc(OC)ccc12 Show InChI InChI=1S/C25H27N3O6S/c1-3-34-24(29)6-4-5-11-28-15-16(19-13-17(33-2)7-10-23(19)28)12-21-20-14-18(35(26,31)32)8-9-22(20)27-25(21)30/h7-10,12-15H,3-6,11H2,1-2H3,(H,27,30)(H2,26,31,32)/b21-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6.96E+3	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Effect on IgE/Fcepsilon RI triggered rat basophil cell (RBL-2H3) degranulation assessed by measuring the amount of 5-HT release				Bioorg Med Chem Lett 13: 3111-4 (2003) BindingDB Entry DOI: 10.7270/Q2ZG6SS7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50132444 (5-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...) Show SMILES CCOC(=O)CCCCn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2cc(OC)ccc12 Show InChI InChI=1S/C25H27N3O6S/c1-3-34-24(29)6-4-5-11-28-15-16(19-13-17(33-2)7-10-23(19)28)12-21-20-14-18(35(26,31)32)8-9-22(20)27-25(21)30/h7-10,12-15H,3-6,11H2,1-2H3,(H,27,30)(H2,26,31,32)/b21-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	678	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis				Bioorg Med Chem Lett 13: 3111-4 (2003) BindingDB Entry DOI: 10.7270/Q2ZG6SS7
					More data for this Ligand-Target Pair