BDBM50132447 5-[5-Methoxy-3-(2-oxo-5-sulfamoyl-1,2-dihydro-indol-3-ylidenemethyl)-indol-1-yl]-pentanoic acid::CHEMBL105438
SMILES: COc1ccc2n(CCCCC(O)=O)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
InChI Key: InChIKey=BBSJLSSZMQQJCX-GRSHGNNSSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM50132447 (5-[5-Methoxy-3-(2-oxo-5-sulfamoyl-1,2-dihydro-indo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis | Bioorg Med Chem Lett 13: 3111-4 (2003) BindingDB Entry DOI: 10.7270/Q2ZG6SS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Immunoglobulin epsilon Fc receptor (Homo sapiens (Human)) | BDBM50132447 (5-[5-Methoxy-3-(2-oxo-5-sulfamoyl-1,2-dihydro-indo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 2.07E+4 | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals Curated by ChEMBL | Assay Description Effect on IgE/Fcepsilon RI triggered rat basophil cell (RBL-2H3) degranulation assessed by measuring the amount of 5-HT release | Bioorg Med Chem Lett 13: 3111-4 (2003) BindingDB Entry DOI: 10.7270/Q2ZG6SS7 | |||||||||||
More data for this Ligand-Target Pair |