BDBM50132582 (2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3-trifluoromethyl-octa-2,4,6-trienoic acid::CHEMBL107554
SMILES: CCCCOc1c(cc(cc1C(C)(C)C)C(C)(C)C)C(\C)=C/C=C/C(=C/C(O)=O)/C(F)(F)F
InChI Key: InChIKey=BQLBHCZTEOUMEY-FETGSKBQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50132582 ((2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]-9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50132582 ((2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]ATRA binding to retinoid acid receptor gamma expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50132582 ((2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 806 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]-9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome Proliferator-Activated Receptor gamma/Retinoid X receptor alpha (Homo sapiens (Human)) | BDBM50132582 ((2Z,4E,6Z)-7-(2-Butoxy-3,5-di-tert-butyl-phenyl)-3...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 359 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity against Retinoic acid receptor RXR-alpha expressed in CV-1 cell transcriptional activation assay | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair |