BDBM50132583 (2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8,8,8-trifluoro-3-methyl-octa-2,4,6-trienoic acid::CHEMBL107555
SMILES: CCOc1c(cc(cc1C(C)(C)C)C(C)(C)C)C(=C/C=C/C(/C)=C/C(O)=O)\C(F)(F)F
InChI Key: InChIKey=IOTZBRPLBMULMD-KLGKYMQISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50132583 ((2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]-9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50132583 ((2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]ATRA binding to retinoid acid receptor gamma expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome Proliferator-Activated Receptor gamma/Retinoid X receptor alpha (Homo sapiens (Human)) | BDBM50132583 ((2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 167 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of 3[H]-9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50132583 ((2E,4E,6E)-7-(3,5-Di-tert-butyl-2-ethoxy-phenyl)-8...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Synergistic activation of BRL49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assay | Bioorg Med Chem Lett 13: 3191-5 (2003) BindingDB Entry DOI: 10.7270/Q2736Q9T | |||||||||||
More data for this Ligand-Target Pair |