BDBM50132653 4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-ylmethyl]-benzonitrile::CHEMBL321685

SMILES: OC1(CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(c1)C(F)(F)F

InChI Key: InChIKey=PJQRBOIVQOGIBZ-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50132653 (4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy...) Show SMILES OC1(CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C20H18ClF3N2O/c21-18-6-5-16(11-17(18)20(22,23)24)19(27)7-9-26(10-8-19)13-15-3-1-14(12-25)2-4-15/h1-6,11,27H,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma L.P. Curated by ChEMBL					Assay Description Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cells				Bioorg Med Chem Lett 13: 3247-52 (2003) BindingDB Entry DOI: 10.7270/Q2K936XQ
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50132653 (4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy...) Show SMILES OC1(CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C20H18ClF3N2O/c21-18-6-5-16(11-17(18)20(22,23)24)19(27)7-9-26(10-8-19)13-15-3-1-14(12-25)2-4-15/h1-6,11,27H,7-10,13H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma L.P. Curated by ChEMBL					Assay Description Binding affinity for recombinant human mu-opioid receptor was determined by using [3H]- diprenophine radioligand				Bioorg Med Chem Lett 14: 5275-9 (2004) Article DOI: 10.1016/j.bmcl.2004.08.032 BindingDB Entry DOI: 10.7270/Q2K073RN
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50132653 (4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy...) Show SMILES OC1(CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C20H18ClF3N2O/c21-18-6-5-16(11-17(18)20(22,23)24)19(27)7-9-26(10-8-19)13-15-3-1-14(12-25)2-4-15/h1-6,11,27H,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma L.P. Curated by ChEMBL					Assay Description Binding affinity for opioid receptor like 1 expressed in HEK-293 cells				Bioorg Med Chem Lett 14: 5275-9 (2004) Article DOI: 10.1016/j.bmcl.2004.08.032 BindingDB Entry DOI: 10.7270/Q2K073RN
					More data for this Ligand-Target Pair