BindingDB PrimarySearch

BDBM50132713 Arachidonic acid derivative::CHEMBL113262::Methyl arachidonoyl fluorophophonate::methyl ((5Z,8Z,11Z,14Z)-2-Icosa-5,8,11,14-tetraenyl)phosphonofluoridoate::methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate::methyl -icosa-5,8,11,14-tetraenylphosphonofluoridate::methyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenylphosphonofluoridate::methylarachidonyl fluorophosphonate

SMILES: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC

InChI Key: InChIKey=KWKZCGMJGHHOKJ-ZKWNWVNESA-N

Data: 17 IC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50132713
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibitory potency of Fatty-acid amide hydrolase with rat brain memebrane				Bioorg Med Chem Lett 13: 3301-3 (2003) BindingDB Entry DOI: 10.7270/Q2XK8DZD
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	26.3	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation counting				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
Universite Catholique de Louvain Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain memebrane				Bioorg Med Chem Lett 13: 3301-3 (2003) BindingDB Entry DOI: 10.7270/Q2XK8DZD
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Anandamide amidohydrolase (Mus musculus (mouse))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibitory potency of Fatty-acid amide hydrolase with Mouse brain memebrane				Bioorg Med Chem Lett 13: 3301-3 (2003) BindingDB Entry DOI: 10.7270/Q2XK8DZD
University of California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 10 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 30 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 90 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 60 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-activating factor acetylhydrolase IB subunit beta (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Shiv Nadar University Curated by ChEMBL					Assay Description Inhibition of PAFAH1B2 (unknown origin) using 2-thiol-PAF as substrate by Ellman's assay				Bioorg Med Chem 24: 3953-3963 (2016) BindingDB Entry DOI: 10.7270/Q2668G45
Shiv Nadar University Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	26.3	n/a	n/a	n/a	n/a	n/a	n/a
Louvain Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human MGL				J Med Chem 52: 7410-20 (2009) Article DOI: 10.1021/jm900461w BindingDB Entry DOI: 10.7270/Q2TM7B59
Louvain Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Louvain Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human FAAH				J Med Chem 52: 7410-20 (2009) Article DOI: 10.1021/jm900461w BindingDB Entry DOI: 10.7270/Q2TM7B59
Louvain Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of FAAH from rat brain microsomes by RP-HPLC				Bioorg Med Chem 18: 945-52 (2010) Article DOI: 10.1016/j.bmc.2009.11.028 BindingDB Entry DOI: 10.7270/Q2N016MF
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
cPLA2 C2 (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of cPLA2 from human platelets by RP-HPLC				Bioorg Med Chem 18: 945-52 (2010) Article DOI: 10.1016/j.bmc.2009.11.028 BindingDB Entry DOI: 10.7270/Q2N016MF
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Catholique de Louvain Curated by ChEMBL					Assay Description Irreversible inhibition of fatty acid amide hydrolase; range=1-3 nM				J Med Chem 48: 5059-87 (2005) Article DOI: 10.1021/jm058183t BindingDB Entry DOI: 10.7270/Q2J96753
Universit£ Catholique de Louvain Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of FAAH				J Med Chem 55: 6898-915 (2012) Article DOI: 10.1021/jm300689c BindingDB Entry DOI: 10.7270/Q2ZK5HSK
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.331	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH-maltose binding protein				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
Universite Catholique de Louvain Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cannabinoid receptor 1 (Mus musculus (Mouse))	BDBM50132713 (Arachidonic acid derivative \| CHEMBL113262 \| Methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain memebrane				Bioorg Med Chem Lett 13: 3301-3 (2003) BindingDB Entry DOI: 10.7270/Q2XK8DZD
University of California Curated by ChEMBL					More data for this Ligand-Target Pair