BDBM50132896 CHEMBL114193::[3-(2,4-Dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-dipropyl-amine
SMILES: CCCN(CCC)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
InChI Key: InChIKey=QTHAUVJVEXYSGF-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50132896 (CHEMBL114193 | [3-(2,4-Dichloro-phenyl)-1,5-dimeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells | Bioorg Med Chem Lett 13: 3371-4 (2003) BindingDB Entry DOI: 10.7270/Q21C1W8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50132896 (CHEMBL114193 | [3-(2,4-Dichloro-phenyl)-1,5-dimeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells | Bioorg Med Chem Lett 13: 3367-70 (2003) BindingDB Entry DOI: 10.7270/Q2542N05 | |||||||||||
More data for this Ligand-Target Pair |