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BDBM50132967 CHEMBL432607::[8-(2,4-Dichloro-phenyl)-2,7-dimethyl-quinolin-4-yl]-dipropyl-amine

SMILES: CCCN(CCC)c1cc(C)nc2c(c(C)ccc12)-c1ccc(Cl)cc1Cl

InChI Key: InChIKey=GEVSQUIJCIWUSL-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50132967   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50132967
PNG
(CHEMBL432607 | [8-(2,4-Dichloro-phenyl)-2,7-dimeth...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)ccc12)-c1ccc(Cl)cc1Cl |(10.69,1.11,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;10.69,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;1.35,1.86,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;1.35,-2.75,;.02,-3.52,;-1.32,-2.75,;-2.65,-3.52,;-1.32,-1.21,;.01,-.44,;.02,1.1,)|
Show InChI InChI=1S/C23H26Cl2N2/c1-5-11-27(12-6-2)21-13-16(4)26-23-19(21)9-7-15(3)22(23)18-10-8-17(24)14-20(18)25/h7-10,13-14H,5-6,11-12H2,1-4H3
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PubMed
 4.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand

Bioorg Med Chem Lett 13: 3375-9 (2003)


BindingDB Entry DOI: 10.7270/Q2WM1CS4
More data for this
Ligand-Target Pair