BDBM50133006 (6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone::(6-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone::CHEMBL338001
SMILES: CN1CCN(CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
InChI Key: InChIKey=YLJOIPRHXDRNJT-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50133006 ((6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]- histamine from the recombinant human histamine H4 receptor | J Med Chem 46: 3957-60 (2003) Article DOI: 10.1021/jm0341047 BindingDB Entry DOI: 10.7270/Q2QJ7J1C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50133006 ((6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells | J Med Chem 48: 8289-98 (2005) Article DOI: 10.1021/jm0502081 BindingDB Entry DOI: 10.7270/Q2C24W00 | |||||||||||
More data for this Ligand-Target Pair |