BDBM50133118 5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phenyl]-thiophen-2-yl}-3-methyl-penta-2,4-dienoic acid::CHEMBL340555
SMILES: CC(C)c1cc(C(C)C)c(OCC(F)F)c(c1)-c1ccsc1\C=C\C(\C)=C\C(O)=O
InChI Key: InChIKey=BWVWYJNVUWUHAQ-XDHFRCMDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoid X receptor beta (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor RXR-beta was determined by competing with 3[H]-9-cis-RA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NR2B Channel Blocker (RAT) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor RXR-alpha was determined by competing with 3[H]-9-cis-RA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor RXR-gamma was determined by competing with 3[H]-9-cis-RA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor alpha (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor alpha was determined by competing with 3[H]-ATRA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Peroxisome proliferator activated receptor gamma was determined | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor beta was determined by competing with 3[H]-ATRA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor gamma (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor gamma was determined by competing with 3[H]-ATRA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor alpha (Rattus norvegicus) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for peroxisome Peroxisome proliferator activated receptor alpha was determined | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor alpha (RAT) | BDBM50133118 (5-{3-[2-(2,2-Difluoro-ethoxy)-3,5-diisopropyl-phen...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity for Retinoic acid receptor RXR-alpha was determined by competing with 3[H]-9-cis-RA | J Med Chem 46: 4087-103 (2003) Article DOI: 10.1021/jm020401k BindingDB Entry DOI: 10.7270/Q2VM4BNR | |||||||||||
More data for this Ligand-Target Pair |