BDBM50133136 5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL415524

SMILES: CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key: InChIKey=VQFLIHCSQSPSJT-QFEZKATASA-N

Data: 3 KI  2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50133136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity towards human progesterone receptor A isoform using progesterone as radioligand				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonistic activity against human progesterone receptor in CV-1 cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	334	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human Mineralocorticoid receptor				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 M				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50133136 (5-[1-(2-Ethyl-phenyl)-meth-(Z)-ylidene]-9-fluoro-2...) Show SMILES CCc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:28| Show InChI InChI=1S/C28H26FNO/c1-5-18-8-6-7-9-19(18)14-25-27-21(22-15-20(29)10-13-24(22)31-25)11-12-23-26(27)17(2)16-28(3,4)30-23/h6-16,30H,5H2,1-4H3/b25-14-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonistic activity against human progesterone receptor in T47D breast cancer cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair