BDBM50133143 7-Fluoro-5-[1-(4-fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL133117

SMILES: CC1=CC(C)(C)Nc2ccc3-c4cccc(F)c4O\C(=C/c4ccc(F)cc4)c3c12

InChI Key: InChIKey=DMQJLSXVZBXUEJ-XKZIYDEJSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50133143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50133143 (7-Fluoro-5-[1-(4-fluoro-phenyl)-meth-(Z)-ylidene]-...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cccc(F)c4O\C(=C/c4ccc(F)cc4)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-12-11-18-19-5-4-6-20(28)25(19)30-22(24(18)23(15)21)13-16-7-9-17(27)10-8-16/h4-14,29H,1-3H3/b22-13-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.710	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity towards human progesterone receptor A isoform using progesterone as radioligand				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50133143 (7-Fluoro-5-[1-(4-fluoro-phenyl)-meth-(Z)-ylidene]-...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cccc(F)c4O\C(=C/c4ccc(F)cc4)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-12-11-18-19-5-4-6-20(28)25(19)30-22(24(18)23(15)21)13-16-7-9-17(27)10-8-16/h4-14,29H,1-3H3/b22-13-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonistic activity against human progesterone receptor in CV-1 cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50133143 (7-Fluoro-5-[1-(4-fluoro-phenyl)-meth-(Z)-ylidene]-...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cccc(F)c4O\C(=C/c4ccc(F)cc4)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-12-11-18-19-5-4-6-20(28)25(19)30-22(24(18)23(15)21)13-16-7-9-17(27)10-8-16/h4-14,29H,1-3H3/b22-13-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonistic activity against human progesterone receptor in T47D breast cancer cells				J Med Chem 46: 4104-12 (2003) Article DOI: 10.1021/jm020477g BindingDB Entry DOI: 10.7270/Q2QZ29C6
					More data for this Ligand-Target Pair