BDBM50133232 (S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-1-yl)-ethylamine::CHEMBL133455
SMILES: C[C@H](N)Cc1c[nH]c2ccc3OCCCc3c12
InChI Key: InChIKey=VVHJUSGIUWQPIT-VIFPVBQESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (5-HT4) (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against human 5-hydroxytryptamine 6 receptor using [3H]LSD radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against 5-hydroxytryptamine 1B receptor using with [125I]- cyanopindolol radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against alpha-1A receptor using [3H]-7-MeO prazosin radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha adrenergic receptor 1A and 1B (Rattus norvegicus (rat)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against Alpha-1B adrenergic radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against norepinephrine transporter receptor using [3H]radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against human serotonin transporter using [3H]N-Me-citalopram radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against 5-hydroxytryptamine 3 receptor using [3H]GR-65630 radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against human 5-hydroxytryptamine 1D receptor using [3H]5-CT radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (NEONATAL RAT) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80.1 | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cells | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50133232 ((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Research, Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand | J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1 | |||||||||||
More data for this Ligand-Target Pair |