BDBM50134097 (3aR,10S)-10-(4-Methoxy-phenyl)-2-pyridin-3-ylmethyl-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione::CHEMBL337770

SMILES: COc1ccc(cc1)[C@H]1c2[nH]c3ccccc3c2Cc2c(O)n(Cc3cccnc3)c(=O)n12

InChI Key: InChIKey=XBJLGMJUQWNVKP-DEOSSOPVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134097   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Bos taurus)	BDBM50134097 ((3aR,10S)-10-(4-Methoxy-phenyl)-2-pyridin-3-ylmeth...) Show SMILES COc1ccc(cc1)[C@H]1c2[nH]c3ccccc3c2Cc2c(O)n(Cc3cccnc3)c(=O)n12 Show InChI InChI=1S/C26H22N4O3/c1-33-18-10-8-17(9-11-18)24-23-20(19-6-2-3-7-21(19)28-23)13-22-25(31)29(26(32)30(22)24)15-16-5-4-12-27-14-16/h2-12,14,24,28,31H,13,15H2,1H3/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibitory activity against bovine PDE5 (phosphodiesterase-5).				J Med Chem 46: 4525-32 (2003) Article DOI: 10.1021/jm030056e BindingDB Entry DOI: 10.7270/Q2NP255G
					More data for this Ligand-Target Pair