BindingDB PrimarySearch

BDBM50134399 1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione::7-Deazaxanthine (7DX)::7-deazaxanthine::CHEMBL122899

SMILES: O=c1[nH]c2[nH]ccc2c(=O)[nH]1

InChI Key: InChIKey=HASUWNAFLUMMFI-UHFFFAOYSA-N

Data: 3 KI 19 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50134399
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of bovine xanthine oxidase using hypoxanthine as a substrate				Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP
The University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	4.91E+4	-5.97	n/a	n/a	n/a	n/a	n/a	n/a	30
University of Karachi					Assay Description In kinetic assay, the TP enzyme (0.058 U/well) was incu- bated with different concentrations of inhibitor (0.5�0.001 mM) for 10 min at 30 C. The rea...				Bioorg Chem 70: 44-56 (2017) Article DOI: 10.1016/j.bioorg.2016.11.007 BindingDB Entry DOI: 10.7270/Q2H70DPM
University of Karachi					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of bovine xanthine oxidase using xanthine as a substrate				Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP
The University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (TP) (Escherichia coli (Enterobacteria))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.87E+4	n/a	n/a	n/a	n/a	7.4	25
Universiti Teknologi MARA (UiTM)					Assay Description The Thymidine phosphorylase/PD-ECGF (E. coli) activity was determined by measuring the absorbance at 290 nm spectrophotometrically. In brief, total r...				Bioorg Chem 68: 80-89 (2016) Article DOI: 10.1016/j.bioorg.2016.07.010 BindingDB Entry DOI: 10.7270/Q2H9940F
Universiti Teknologi MARA (UiTM)					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	30
University of Karachi					Assay Description TP inhibition assay was performed spectrophotometrically in 96-well plate. The method of Bera et al. was followed with slight modifications [Bera et ...				Bioorg Chem 70: 44-56 (2017) Article DOI: 10.1016/j.bioorg.2016.11.007 BindingDB Entry DOI: 10.7270/Q2H70DPM
University of Karachi					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidine to thymine after 4 to 20 mi...				Eur J Med Chem 78: 294-303 (2014) Article DOI: 10.1016/j.ejmech.2014.03.063 BindingDB Entry DOI: 10.7270/Q2SF2XP4
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of Thymidine phosphorylase from Escherichia coli				Bioorg Med Chem Lett 14: 5247-50 (2004) Article DOI: 10.1016/j.bmcl.2004.08.036 BindingDB Entry DOI: 10.7270/Q2PR7VGP
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase				Eur J Med Chem 43: 1248-60 (2008) Article DOI: 10.1016/j.ejmech.2007.07.015 BindingDB Entry DOI: 10.7270/Q2Z31ZDP
The University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against Escherichia coli thymidine phosphorylase				Bioorg Med Chem Lett 13: 3705-9 (2003) BindingDB Entry DOI: 10.7270/Q2SQ90ZZ
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory concentration against thymidine phosphorylase of Escherichia coli				J Med Chem 48: 392-402 (2005) Article DOI: 10.1021/jm049494r BindingDB Entry DOI: 10.7270/Q2445N8K
University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AIMST University Curated by ChEMBL					Assay Description Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting method				Eur J Med Chem 124: 992-1003 (2016) Article DOI: 10.1016/j.ejmech.2016.10.032 BindingDB Entry DOI: 10.7270/Q2RR218S
AIMST University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Imam Abdulrahman Bin Faisal University Curated by ChEMBL					Assay Description Inhibition of Escherichia coli thymidine phosphorylase pretreated for 10 mins followed by substrate addition measured at 10 mins interval for 30 mins...				Bioorg Med Chem 26: 3654-3663 (2018) Article DOI: 10.1016/j.bmc.2018.05.046 BindingDB Entry DOI: 10.7270/Q22V2JKV
Imam Abdulrahman Bin Faisal University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yunnan University Curated by ChEMBL					Assay Description Inhibition of thymidine phosphorylase (unknown origin) using thymidine as substrate after 1 hr by spectrophotometric analysis				Eur J Med Chem 144: 41-51 (2018) Article DOI: 10.1016/j.ejmech.2017.12.016 BindingDB Entry DOI: 10.7270/Q24M9762
Yunnan University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Karachi Curated by ChEMBL					Assay Description Inhibition of Escherichia coli thymidine phosphorylase by spectrophotometry				J Nat Prod 69: 957-9 (2006) Article DOI: 10.1021/np050221o BindingDB Entry DOI: 10.7270/Q20P12TG
University of Karachi Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Information Technology Curated by ChEMBL					Assay Description Inhibition of Escherichia coli thymidine phosphorylase using thymidine 5' mono phosphate as substrate after 10 mins by spectrophotometric analysis				Bioorg Med Chem 22: 1008-15 (2014) Article DOI: 10.1016/j.bmc.2013.12.043 BindingDB Entry DOI: 10.7270/Q25T3PFP
Institute of Information Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Escherichia coli)	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Karachi Curated by ChEMBL					Assay Description Inhibition of Escherichia coli thymidine phosphorylase				Bioorg Med Chem 17: 2983-8 (2009) Article DOI: 10.1016/j.bmc.2009.03.020 BindingDB Entry DOI: 10.7270/Q2GX4FC3
University of Karachi Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Jining Medical University Curated by ChEMBL					Assay Description Inhibition of human recombinant BACE-1 using 19F peptide as substrate measured after 5 hrs by fluorescence method				Eur J Med Chem 169: 200-223 (2019) Article DOI: 10.1016/j.ejmech.2019.02.076
Jining Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Jining Medical University Curated by ChEMBL					Assay Description Inhibition of human recombinant GSK-3beta using 19F peptide as substrate measured after 1.5 hrs by fluorescence method				Eur J Med Chem 169: 200-223 (2019) Article DOI: 10.1016/j.ejmech.2019.02.076
Jining Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (TP) (Escherichia coli (Enterobacteria))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	7.0	n/a
University of Karachi					Assay Description TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 �...				Bioorg Chem 63: 142-51 (2015) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2C8282R
University of Karachi					More data for this Ligand-Target Pair
Thymidine phosphorylase (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Pampa Curated by ChEMBL					Assay Description Inhibition of thymidine phosphorylase (unknown origin)				J Med Chem 62: 1231-1245 (2019) Article DOI: 10.1021/acs.jmedchem.8b01305
Universidade Federal do Pampa Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine Phosphorylase (TP) (Homo sapiens (Human))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate after 4 to 20 mins by spectrophoto...				Eur J Med Chem 67: 325-34 (2013) Article DOI: 10.1016/j.ejmech.2013.06.051 BindingDB Entry DOI: 10.7270/Q2QR4ZJ0
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidine phosphorylase (TP) (Escherichia coli (Enterobacteria))	BDBM50134399 (1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione \| 7...) Show SMILES O=c1[nH]c2[nH]ccc2c(=O)[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.87E+4	n/a	n/a	n/a	n/a	7.4	n/a
COMSATS Institute of Information Technology					Assay Description Briefly, a total reaction mixture of 200 �l contained 145 �l of potassium phosphate buffer (pH 7.4), 30 �l of enzyme at concentration 0.05 and 0.002 ...				Bioorg Chem 60: 37-41 (2015) Article DOI: 10.1016/j.bioorg.2015.04.003 BindingDB Entry DOI: 10.7270/Q2JH3JW5
COMSATS Institute of Information Technology					More data for this Ligand-Target Pair