BDBM50134580 1,2,3,8-tetrahydro-benzo[a]pyrrolo[3,4-c]carbazole-1,3-dione::1,2,3,8-tetrahydrobenzo[a]pyrrolo[4,3-c]carbazole-1,3-dione::CHEMBL421087::benzo(a)pyrrolo(3,4-c)carbazole-1,3(2H,8H)-dione

SMILES: O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1ccccc21

InChI Key: InChIKey=IUWAGZUDXHNNFN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50134580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM50134580 (1,2,3,8-tetrahydro-benzo[a]pyrrolo[3,4-c]carbazole...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1ccccc21 Show InChI InChI=1S/C18H10N2O2/c21-17-14-9-5-1-2-6-10(9)16-13(15(14)18(22)20-17)11-7-3-4-8-12(11)19-16/h1-8,19H,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université d'Orléans Curated by ChEMBL					Assay Description Inhibitory activity against CDK5/p25				J Med Chem 49: 789-99 (2006) Article DOI: 10.1021/jm050945x BindingDB Entry DOI: 10.7270/Q2QZ29JF
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM50134580 (1,2,3,8-tetrahydro-benzo[a]pyrrolo[3,4-c]carbazole...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1ccccc21 Show InChI InChI=1S/C18H10N2O2/c21-17-14-9-5-1-2-6-10(9)16-13(15(14)18(22)20-17)11-7-3-4-8-12(11)19-16/h1-8,19H,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Spain S.A. Curated by ChEMBL					Assay Description Inhibition of Cyclin E-cyclin-dependent kinase 2				Bioorg Med Chem Lett 13: 3835-9 (2003) BindingDB Entry DOI: 10.7270/Q2Z89BTC
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50134580 (1,2,3,8-tetrahydro-benzo[a]pyrrolo[3,4-c]carbazole...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1ccccc21 Show InChI InChI=1S/C18H10N2O2/c21-17-14-9-5-1-2-6-10(9)16-13(15(14)18(22)20-17)11-7-3-4-8-12(11)19-16/h1-8,19H,(H,20,21,22)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human PARP1 expressed in PC12 cells				Bioorg Med Chem Lett 16: 938-42 (2006) Article DOI: 10.1016/j.bmcl.2005.10.099 BindingDB Entry DOI: 10.7270/Q2222TB3
					More data for this Ligand-Target Pair