BDBM50134581 5,6,7,14-tetrahydronaphtho[3,2-a]pyrrolo[4,3-c]carbazole-5,7-dione::CHEMBL341503

SMILES: O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1cc3ccccc3cc21

InChI Key: InChIKey=RONAHYSBEQPGHS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134581   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM50134581 (5,6,7,14-tetrahydronaphtho[3,2-a]pyrrolo[4,3-c]car...) Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1cc3ccccc3cc21 Show InChI InChI=1S/C22H12N2O2/c25-21-18-14-9-11-5-1-2-6-12(11)10-15(14)20-17(19(18)22(26)24-21)13-7-3-4-8-16(13)23-20/h1-10,23H,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Spain S.A. Curated by ChEMBL					Assay Description Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbING				Bioorg Med Chem Lett 13: 3835-9 (2003) BindingDB Entry DOI: 10.7270/Q2Z89BTC
					More data for this Ligand-Target Pair