BDBM50134847 4-(3-Ethyl-1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]quinazolin-8-yl)-piperazine-1-carbothioic acid benzylamide::CHEMBL434262

SMILES: CCn1c2cc3ncnc(N4CCN(CC4)C(=S)NCc4ccccc4)c3cc2n(C)c1=O

InChI Key: InChIKey=HFCYEHKOQAJLRK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50134847 (4-(3-Ethyl-1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4...) Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=S)NCc4ccccc4)c3cc2n(C)c1=O Show InChI InChI=1S/C24H27N7OS/c1-3-31-21-14-19-18(13-20(21)28(2)24(31)32)22(27-16-26-19)29-9-11-30(12-10-29)23(33)25-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,25,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...				J Med Chem 46: 4910-25 (2003) Article DOI: 10.1021/jm020505v BindingDB Entry DOI: 10.7270/Q2X929PJ
					More data for this Ligand-Target Pair