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SMILES: FC(F)(F)c1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=VNFPJNRINGAMEJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134873   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50134873
PNG
(4-(7-Trifluoromethyl-quinolin-4-yl)-piperazine-1-c...)
Show SMILES FC(F)(F)c1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H23F3N4O2/c28-27(29,30)19-6-11-23-24(18-19)31-13-12-25(23)33-14-16-34(17-15-33)26(35)32-20-7-9-22(10-8-20)36-21-4-2-1-3-5-21/h1-13,18H,14-17H2,(H,32,35)
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Article
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n/an/a 550n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...

J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
BindingDB Entry DOI: 10.7270/Q2X929PJ
More data for this
Ligand-Target Pair