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SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OCC(O)=O

InChI Key: InChIKey=PYKIKNQSEGQCGL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134887   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50134887
PNG
(CHEMBL148221 | {4-[4-(4-Cyano-phenylcarbamoyl)-pip...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OCC(O)=O
Show InChI InChI=1S/C23H22N6O5/c1-33-19-11-18-17(10-20(19)34-13-21(30)31)22(26-14-25-18)28-6-8-29(9-7-28)23(32)27-16-4-2-15(12-24)3-5-16/h2-5,10-11,14H,6-9,13H2,1H3,(H,27,32)(H,30,31)
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Similars
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...

J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
BindingDB Entry DOI: 10.7270/Q2X929PJ
More data for this
Ligand-Target Pair