BDBM50134889 4-(6-Methoxy-7-prop-2-ynyloxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL148259

SMILES: COc1cc2c(ncnc2cc1OCC#C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=VKJCYNFKNMOZKV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134889   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50134889 (4-(6-Methoxy-7-prop-2-ynyloxy-quinazolin-4-yl)-pip...) Show SMILES COc1cc2c(ncnc2cc1OCC#C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H27N5O4/c1-3-17-37-27-19-25-24(18-26(27)36-2)28(31-20-30-25)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h1,4-12,18-20H,13-17H2,2H3,(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...				J Med Chem 46: 4910-25 (2003) Article DOI: 10.1021/jm020505v BindingDB Entry DOI: 10.7270/Q2X929PJ
					More data for this Ligand-Target Pair