BDBM50134908 4-(3-Ethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]quinazolin-8-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL147325

SMILES: CCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2[nH]c1=O

InChI Key: InChIKey=ZTPUTDMDORDJGQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50134908 (4-(3-Ethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]quin...) Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2[nH]c1=O Show InChI InChI=1S/C28H27N7O3/c1-2-35-25-17-23-22(16-24(25)32-28(35)37)26(30-18-29-23)33-12-14-34(15-13-33)27(36)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18H,2,12-15H2,1H3,(H,31,36)(H,32,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...				J Med Chem 46: 4910-25 (2003) Article DOI: 10.1021/jm020505v BindingDB Entry DOI: 10.7270/Q2X929PJ
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