BDBM50135312 6-(2-Chloro-4-fluoro-phenylsulfanyl)-1-(2,6-dichloro-phenyl)-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one::CHEMBL128813

SMILES: Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cccc2Cl)c(Cl)c1

InChI Key: InChIKey=WDCXQMIUZVKFEE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50135312 (6-(2-Chloro-4-fluoro-phenylsulfanyl)-1-(2,6-dichlo...) Show SMILES Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3FN3OS/c20-11-2-1-3-12(21)18(11)26-15-5-7-17(25-14(15)9-24-19(26)27)28-16-6-4-10(23)8-13(16)22/h1-8H,9H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against mitogen-activated protein kinase p38 beta				Bioorg Med Chem Lett 13: 3979-82 (2003) BindingDB Entry DOI: 10.7270/Q2RJ4HWB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50135312 (6-(2-Chloro-4-fluoro-phenylsulfanyl)-1-(2,6-dichlo...) Show SMILES Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3FN3OS/c20-11-2-1-3-12(21)18(11)26-15-5-7-17(25-14(15)9-24-19(26)27)28-16-6-4-10(23)8-13(16)22/h1-8H,9H2,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha				Bioorg Med Chem Lett 13: 3979-82 (2003) BindingDB Entry DOI: 10.7270/Q2RJ4HWB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50135312 (6-(2-Chloro-4-fluoro-phenylsulfanyl)-1-(2,6-dichlo...) Show SMILES Fc1ccc(Sc2ccc3N(C(=O)NCc3n2)c2c(Cl)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C19H11Cl3FN3OS/c20-11-2-1-3-12(21)18(11)26-15-5-7-17(25-14(15)9-24-19(26)27)28-16-6-4-10(23)8-13(16)22/h1-8H,9H2,(H,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha				Bioorg Med Chem Lett 13: 3979-82 (2003) BindingDB Entry DOI: 10.7270/Q2RJ4HWB
					More data for this Ligand-Target Pair