BindingDB PrimarySearch

BDBM50135353 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile::CHEMBL128309

SMILES: Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(cc1)C#N

InChI Key: InChIKey=AECLAEDYDCKFJG-UHFFFAOYSA-N

Data: 3 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50135353
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration of the compound against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair