BDBM50135355 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile::CHEMBL131170

SMILES: Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OC(F)(F)Oc2c1)c1ccc(cc1)C#N

InChI Key: InChIKey=ONSUIKYVBGOGPD-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135355 (6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OC(F)(F)Oc2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F2N5O4/c1-33-15-32-13-21(33)25(17-5-3-16(11-30)4-6-17)36-14-22-20(9-19(12-31)26(35)34(22)2)18-7-8-23-24(10-18)38-27(28,29)37-23/h3-10,13,15,25H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135355 (6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OC(F)(F)Oc2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F2N5O4/c1-33-15-32-13-21(33)25(17-5-3-16(11-30)4-6-17)36-14-22-20(9-19(12-31)26(35)34(22)2)18-7-8-23-24(10-18)38-27(28,29)37-23/h3-10,13,15,25H,14H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135355 (6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc2OC(F)(F)Oc2c1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F2N5O4/c1-33-15-32-13-21(33)25(17-5-3-16(11-30)4-6-17)36-14-22-20(9-19(12-31)26(35)34(22)2)18-7-8-23-24(10-18)38-27(28,29)37-23/h3-10,13,15,25H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration of the compound against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair