BDBM50135369 5-(3-Chloro-4-fluoro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile::CHEMBL132337

SMILES: Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(F)c(Cl)c1)c1ccc(cc1)C#N

InChI Key: InChIKey=ZGQAAHNNGHYZAB-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135369   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135369 (5-(3-Chloro-4-fluoro-phenyl)-6-[(4-cyano-phenyl)-(...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(F)c(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClFN5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-20(9-19(12-30)26(34)33(24)2)18-7-8-22(28)21(27)10-18/h3-10,13,15,25H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135369 (5-(3-Chloro-4-fluoro-phenyl)-6-[(4-cyano-phenyl)-(...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(F)c(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClFN5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-20(9-19(12-30)26(34)33(24)2)18-7-8-22(28)21(27)10-18/h3-10,13,15,25H,14H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135369 (5-(3-Chloro-4-fluoro-phenyl)-6-[(4-cyano-phenyl)-(...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(F)c(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClFN5O2/c1-32-15-31-13-23(32)25(17-5-3-16(11-29)4-6-17)35-14-24-20(9-19(12-30)26(34)33(24)2)18-7-8-22(28)21(27)10-18/h3-10,13,15,25H,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration of the compound against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair