BDBM50135370 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile::CHEMBL132283

SMILES: Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1

InChI Key: InChIKey=QFVRKKGXFGGVET-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135370 (6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C32H23Cl2N5O2/c1-38-19-37-17-29(38)31(22-9-10-23(15-35)27(13-22)20-5-3-7-25(33)11-20)41-18-30-28(21-6-4-8-26(34)12-21)14-24(16-36)32(40)39(30)2/h3-14,17,19,31H,18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration of the compound against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135370 (6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C32H23Cl2N5O2/c1-38-19-37-17-29(38)31(22-9-10-23(15-35)27(13-22)20-5-3-7-25(33)11-20)41-18-30-28(21-6-4-8-26(34)12-21)14-24(16-36)32(40)39(30)2/h3-14,17,19,31H,18H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50135370 (6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C32H23Cl2N5O2/c1-38-19-37-17-29(38)31(22-9-10-23(15-35)27(13-22)20-5-3-7-25(33)11-20)41-18-30-28(21-6-4-8-26(34)12-21)14-24(16-36)32(40)39(30)2/h3-14,17,19,31H,18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against farnesyltransferase (FT)				Bioorg Med Chem Lett 13: 4001-5 (2003) BindingDB Entry DOI: 10.7270/Q2H41QVX
					More data for this Ligand-Target Pair