Found 3 hits for monomerid = 50135381 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135381
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1[nH]c(=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O2/c1-31-15-29-13-23(31)24(17-7-5-16(11-27)6-8-17)33-14-22-21(10-19(12-28)25(32)30-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135381
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1[nH]c(=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O2/c1-31-15-29-13-23(31)24(17-7-5-16(11-27)6-8-17)33-14-22-21(10-19(12-28)25(32)30-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3,(H,30,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135381
(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)Show SMILES Cn1cncc1C(OCc1[nH]c(=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C25H18ClN5O2/c1-31-15-29-13-23(31)24(17-7-5-16(11-27)6-8-17)33-14-22-21(10-19(12-28)25(32)30-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3,(H,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro effective concentration of the compound against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
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