Found 3 hits for monomerid = 50135386 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135386
(5-(3-Chloro-phenyl)-6-[(4-cyano-3-iodo-phenyl)-(3-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(I)c1 Show InChI InChI=1S/C26H19ClIN5O2/c1-32-15-31-13-23(32)25(17-6-7-18(11-29)22(28)10-17)35-14-24-21(16-4-3-5-20(27)8-16)9-19(12-30)26(34)33(24)2/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 88 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro effective concentration of the compound against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135386
(5-(3-Chloro-phenyl)-6-[(4-cyano-3-iodo-phenyl)-(3-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(I)c1 Show InChI InChI=1S/C26H19ClIN5O2/c1-32-15-31-13-23(32)25(17-6-7-18(11-29)22(28)10-17)35-14-24-21(16-4-3-5-20(27)8-16)9-19(12-30)26(34)33(24)2/h3-10,13,15,25H,14H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135386
(5-(3-Chloro-phenyl)-6-[(4-cyano-3-iodo-phenyl)-(3-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(C#N)c(I)c1 Show InChI InChI=1S/C26H19ClIN5O2/c1-32-15-31-13-23(32)25(17-6-7-18(11-29)22(28)10-17)35-14-24-21(16-4-3-5-20(27)8-16)9-19(12-30)26(34)33(24)2/h3-10,13,15,25H,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this Ligand-Target Pair | |