Found 3 hits for monomerid = 50135388 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135388
(6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C33H23ClF3N5O3/c1-41-19-40-17-29(41)31(22-6-7-23(15-38)27(13-22)21-4-3-5-25(34)12-21)44-18-30-28(14-24(16-39)32(43)42(30)2)20-8-10-26(11-9-20)45-33(35,36)37/h3-14,17,19,31H,18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135388
(6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C33H23ClF3N5O3/c1-41-19-40-17-29(41)31(22-6-7-23(15-38)27(13-22)21-4-3-5-25(34)12-21)44-18-30-28(14-24(16-39)32(43)42(30)2)20-8-10-26(11-9-20)45-33(35,36)37/h3-14,17,19,31H,18H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50135388
(6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-...)Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1ccc(OC(F)(F)F)cc1)c1ccc(C#N)c(c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C33H23ClF3N5O3/c1-41-19-40-17-29(41)31(22-6-7-23(15-38)27(13-22)21-4-3-5-25(34)12-21)44-18-30-28(14-24(16-39)32(43)42(30)2)20-8-10-26(11-9-20)45-33(35,36)37/h3-14,17,19,31H,18H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro effective concentration of the compound against farnesyltransferase (FT) |
Bioorg Med Chem Lett 13: 4001-5 (2003)
BindingDB Entry DOI: 10.7270/Q2H41QVX |
More data for this
Ligand-Target Pair | |
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