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BDBM50135401 CHEMBL130943::[5-(3-Methoxy-5-trifluoromethyl-phenylcarbamoyl)-4-methyl-thiazol-2-yl]-carbamic acid tert-butyl ester

SMILES: COc1cc(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2C)cc(c1)C(F)(F)F

InChI Key: InChIKey=PKISAKMOTUYTCV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase LCK


(Mus musculus)		BDBM50135401
PNG
(CHEMBL130943 | [5-(3-Methoxy-5-trifluoromethyl-phe...)
Show SMILES COc1cc(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N3O4S/c1-9-13(29-15(22-9)24-16(26)28-17(2,3)4)14(25)23-11-6-10(18(19,20)21)7-12(8-11)27-5/h6-8H,1-5H3,(H,23,25)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.

Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair