BDBM50135404 2-(Cyclopropanecarbonyl-amino)-thiazole-5-carboxylic acid (2,4,6-trimethyl-phenyl)-amide::CHEMBL339037

SMILES: Cc1cc(C)c(NC(=O)c2cnc(NC(=O)C3CC3)s2)c(C)c1

InChI Key: InChIKey=OTRYTNJSIZLUNP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50135404 (2-(Cyclopropanecarbonyl-amino)-thiazole-5-carboxyl...) Show SMILES Cc1cc(C)c(NC(=O)c2cnc(NC(=O)C3CC3)s2)c(C)c1 Show InChI InChI=1S/C17H19N3O2S/c1-9-6-10(2)14(11(3)7-9)19-16(22)13-8-18-17(23-13)20-15(21)12-4-5-12/h6-8,12H,4-5H2,1-3H3,(H,19,22)(H,18,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity of the compound human Lck(hLck) kinase				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair