BDBM50135496 CHEMBL130156::[4-(5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonylamino)-3-methanesulfonyl-benzoylamino]-acetic acid

SMILES: Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1ccc(cc1S(C)(=O)=O)C(=O)NCC(O)=O

InChI Key: InChIKey=NGSKAGQGUIPLFV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50135496 (CHEMBL130156 | [4-(5-Fluoro-3-methyl-benzo[b]thiop...) Show SMILES Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1ccc(cc1S(C)(=O)=O)C(=O)NCC(O)=O Show InChI InChI=1S/C19H17FN2O7S3/c1-10-13-8-12(20)4-6-15(13)30-19(10)32(28,29)22-14-5-3-11(7-16(14)31(2,26)27)18(25)21-9-17(23)24/h3-8,22H,9H2,1-2H3,(H,21,25)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	154	n/a	n/a	n/a	n/a	n/a	n/a
Toa Eiyo Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human chymase				Bioorg Med Chem Lett 13: 4085-8 (2003) BindingDB Entry DOI: 10.7270/Q2QN665P
					More data for this Ligand-Target Pair