BDBM50135851 2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenoxy)-phenol::2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol::CHEMBL150098
SMILES: Oc1c(Br)cc(Br)cc1Oc1c(O)c(Br)c(Br)c(Br)c1Br
InChI Key: InChIKey=OMYZFHYKAPRFFQ-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aldose reductase (AR) (Homo sapiens (Human)) | BDBM50135851 (2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A. Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined | J Med Chem 46: 5208-21 (2003) Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
12-Lipoxygenase (12-LOX) (Homo sapiens (Human)) | BDBM50135851 (2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory effect on human platelet 12-lipoxygenase | J Med Chem 47: 4060-5 (2004) Article DOI: 10.1021/jm049872s BindingDB Entry DOI: 10.7270/Q2SX6CPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50135851 (2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of Bak binding to Mcl-1 by FRET assay | J Nat Prod 72: 443-9 (2009) Article DOI: 10.1021/np800737z BindingDB Entry DOI: 10.7270/Q2XW4NMD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 15-lipoxygenase (Homo sapiens (Human)) | BDBM50135851 (2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of 15-lipoxygenase | J Nat Prod 58: 1384-1391 (1995) Article DOI: 10.1021/np50123a008 BindingDB Entry DOI: 10.7270/Q22B8Z26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 15-lipoxygenase (Homo sapiens (Human)) | BDBM50135851 (2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibitory effect on human reticulocyte 15-lipoxygenase | J Med Chem 47: 4060-5 (2004) Article DOI: 10.1021/jm049872s BindingDB Entry DOI: 10.7270/Q2SX6CPV | |||||||||||
More data for this Ligand-Target Pair |