BDBM50135883 (2R)-1-(2,6-dimethylphenoxy)propan-2-amine::(R)-1-(2,6-dimethylphenoxy)propan-2-amine::(R)-2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine::CHEMBL147507::MEXILETINE
SMILES: C[C@@H](N)COc1c(C)cccc1C
InChI Key: InChIKey=VLPIATFUUWWMKC-SNVBAGLBSA-N
Data: 2 IC50 1 EC50
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50135883 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM50135883
((2R)-1-(2,6-dimethylphenoxy)propan-2-amine | (R)-1...)Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Therapeutics Ltd
Curated by ChEMBL
| Assay Description Inhibition of uPA |
J Med Chem 51: 183-6 (2008)
Article DOI: 10.1021/jm701359z BindingDB Entry DOI: 10.7270/Q2XG9QWK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
(Homo sapiens (Human)) | BDBM50135883
((2R)-1-(2,6-dimethylphenoxy)propan-2-amine | (R)-1...)Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.29E+4 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current |
Eur J Med Chem 44: 1477-85 (2009)
Article DOI: 10.1016/j.ejmech.2008.10.005 BindingDB Entry DOI: 10.7270/Q2M61MGC |
More data for this Ligand-Target Pair | |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM50135883
((2R)-1-(2,6-dimethylphenoxy)propan-2-amine | (R)-1...)Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Therapeutics Ltd.
Curated by ChEMBL
| Assay Description Inhibition of uPA |
J Med Chem 51: 3661-80 (2008)
Article DOI: 10.1021/jm8000373 BindingDB Entry DOI: 10.7270/Q2N58M4H |
More data for this Ligand-Target Pair | 3D Structure (crystal) |