BDBM50135960 2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL151750

SMILES: COc1ccc(c(CN)c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)C(F)(F)F

InChI Key: InChIKey=DLEIXRRRDBCOKW-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135960   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50135960 (2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...) Show SMILES COc1ccc(c(CN)c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C25H21F4N5O4S/c1-38-16-7-9-20(15(10-16)13-30)34-21(12-23(33-34)25(27,28)29)24(35)32-19-8-6-14(11-18(19)26)17-4-2-3-5-22(17)39(31,36)37/h2-12H,13,30H2,1H3,(H,32,35)(H2,31,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Tested in vitro for inhibition of human Coagulation factor X				J Med Chem 46: 5298-315 (2003) Article DOI: 10.1021/jm030212h BindingDB Entry DOI: 10.7270/Q2ZW1MP2
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50135960 (2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...) Show SMILES COc1ccc(c(CN)c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C25H21F4N5O4S/c1-38-16-7-9-20(15(10-16)13-30)34-21(12-23(33-34)25(27,28)29)24(35)32-19-8-6-14(11-18(19)26)17-4-2-3-5-22(17)39(31,36)37/h2-12H,13,30H2,1H3,(H,32,35)(H2,31,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Tested in vitro for inhibition of human trypsin				J Med Chem 46: 5298-315 (2003) Article DOI: 10.1021/jm030212h BindingDB Entry DOI: 10.7270/Q2ZW1MP2
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50135960 (2-(2-Aminomethyl-4-methoxy-phenyl)-5-trifluorometh...) Show SMILES COc1ccc(c(CN)c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C25H21F4N5O4S/c1-38-16-7-9-20(15(10-16)13-30)34-21(12-23(33-34)25(27,28)29)24(35)32-19-8-6-14(11-18(19)26)17-4-2-3-5-22(17)39(31,36)37/h2-12H,13,30H2,1H3,(H,32,35)(H2,31,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro for inhibition of human thrombin				J Med Chem 46: 5298-315 (2003) Article DOI: 10.1021/jm030212h BindingDB Entry DOI: 10.7270/Q2ZW1MP2
					More data for this Ligand-Target Pair