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BDBM50136234 CHEMBL132589::FR-181157::Sodium; {3-[(R)-2-(4,5-diphenyl-oxazol-2-yl)-cyclohex-2-enylmethyl]-phenoxy}-acetate::Sodium; {3-[(S)-2-(4,5-diphenyl-oxazol-2-yl)-cyclohex-2-enylmethyl]-phenoxy}-acetate::Sodium; {3-[2-(4,5-diphenyl-oxazol-2-yl)-cyclohex-2-enylmethyl]-phenoxy}-acetate::sodium (S)-2-(3-((2-(4,5-diphenyloxazol-2-yl)cyclohex-2-enyl)methyl)phenoxy)acetate

SMILES: [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1

InChI Key: InChIKey=QVZSFHJAGXKMMQ-UHFFFAOYSA-M

Data: 18 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50136234   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostacyclin receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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54n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]-Iloprost radioligand from cloned human IP receptor


Bioorg Med Chem Lett 13: 4277-9 (2003)


BindingDB Entry DOI: 10.7270/Q22R3R3D
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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54n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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54n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Iloprost binding to human prostanoid IP receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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60n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]iloprost from cloned human PGI2 receptor


Bioorg Med Chem Lett 16: 4861-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.076
BindingDB Entry DOI: 10.7270/Q2R49QD9
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGF-2 binding to human prostanoid FP receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Thromboxane A2 receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human Prostanoid TP receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to human prostanoid EP2 receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibtion of [3H]-PGD-2 binding to human prostanoid DP receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Thromboxane A2 receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SQ-29,548 binding to human prostanoid TP receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to human prostanoid EP3 receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to human prostanoid EP1 receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to Prostanoid EP1 receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGF-2 binding to human Prostanoid FP receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGD-2 binding to human Prostanoid DP receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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>1.00E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to Prostanoid EP2 receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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1.02E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to human prostanoid EP4 receptor


J Med Chem 48: 3103-6 (2005)


Article DOI: 10.1021/jm050085k
BindingDB Entry DOI: 10.7270/Q2XD116M
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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1.02E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to Prostanoid EP4 receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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PubMed
6.80E+3n/an/an/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PGE-2 binding to Prostanoid EP3 receptor


Bioorg Med Chem Lett 15: 3284-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.076
BindingDB Entry DOI: 10.7270/Q2C53KCV
More data for this
Ligand-Target Pair
Prostacyclin receptor


(RAT)
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation


Bioorg Med Chem Lett 16: 4861-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.076
BindingDB Entry DOI: 10.7270/Q2R49QD9
More data for this
Ligand-Target Pair
Prostacyclin receptor


(Homo sapiens (Human))
BDBM50136234
PNG
(CHEMBL132589 | FR-181157 | Sodium; {3-[(R)-2-(4,5-...)
Show SMILES [O-]C(=O)COc1cccc(CC2CCCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:15|
Show InChI InChI=1S/C30H27NO4/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33)/p-1
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PubMed
n/an/a 60n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation


Bioorg Med Chem Lett 16: 4861-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.076
BindingDB Entry DOI: 10.7270/Q2R49QD9
More data for this
Ligand-Target Pair