BDBM50137175 2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzylamino}-2-methyl-propan-1-ol::CHEMBL308498

SMILES: CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1

InChI Key: InChIKey=KJTNEZSZMBPREH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50137175   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50137175 (2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...) Show SMILES CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1 Show InChI InChI=1S/C25H25N5OS/c1-25(2,14-31)29-13-16-3-5-17(6-4-16)22-12-21-23(32-22)24(28-15-27-21)30-19-7-8-20-18(11-19)9-10-26-20/h3-12,15,26,29,31H,13-14H2,1-2H3,(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against Vascular endothelial growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50137175 (2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...) Show SMILES CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1 Show InChI InChI=1S/C25H25N5OS/c1-25(2,14-31)29-13-16-3-5-17(6-4-16)22-12-21-23(32-22)24(28-15-27-21)30-19-7-8-20-18(11-19)9-10-26-20/h3-12,15,26,29,31H,13-14H2,1-2H3,(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50137175 (2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...) Show SMILES CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1 Show InChI InChI=1S/C25H25N5OS/c1-25(2,14-31)29-13-16-3-5-17(6-4-16)22-12-21-23(32-22)24(28-15-27-21)30-19-7-8-20-18(11-19)9-10-26-20/h3-12,15,26,29,31H,13-14H2,1-2H3,(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against Vascular endothelial growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50137175 (2-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...) Show SMILES CC(C)(CO)NCc1ccc(cc1)-c1cc2ncnc(Nc3ccc4[nH]ccc4c3)c2s1 Show InChI InChI=1S/C25H25N5OS/c1-25(2,14-31)29-13-16-3-5-17(6-4-16)22-12-21-23(32-22)24(28-15-27-21)30-19-7-8-20-18(11-19)9-10-26-20/h3-12,15,26,29,31H,13-14H2,1-2H3,(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair