BDBM50137185 (1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4-yl)-amine::CHEMBL76432

SMILES: N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1

InChI Key: InChIKey=CGDLXUGHZUDIDJ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50137185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against Vascular endothelial growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Ferrara Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin)				J Med Chem 62: 1274-1290 (2019) Article DOI: 10.1021/acs.jmedchem.8b01391
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Ferrara Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				J Med Chem 62: 1274-1290 (2019) Article DOI: 10.1021/acs.jmedchem.8b01391
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50137185 ((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...) Show SMILES N(c1ccc2[nH]ccc2c1)c1ncnc2cc(sc12)-c1ccccc1 Show InChI InChI=1S/C20H14N4S/c1-2-4-13(5-3-1)18-11-17-19(25-18)20(23-12-22-17)24-15-6-7-16-14(10-15)8-9-21-16/h1-12,21H,(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor				Bioorg Med Chem Lett 14: 21-4 (2003) BindingDB Entry DOI: 10.7270/Q2FT8KFT
					More data for this Ligand-Target Pair