BDBM50137349 1-Cyano-4-ethoxy-2-oxo-2H-3-oxa-benzo[a]azulene-10-carboxylic acid ethyl ester::CHEMBL157082

SMILES: CCOC(=O)c1c2cccccc2c2c(OCC)oc(=O)c(C#N)c12

InChI Key: InChIKey=DFYSBOCNWBIFDR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50137349   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Homo sapiens (Human))	BDBM50137349 (1-Cyano-4-ethoxy-2-oxo-2H-3-oxa-benzo[a]azulene-10...) Show SMILES CCOC(=O)c1c2cccccc2c2c(OCC)oc(=O)c(C#N)c12 Show InChI InChI=1S/C19H15NO5/c1-3-23-18(22)15-11-8-6-5-7-9-12(11)16-14(15)13(10-20)17(21)25-19(16)24-4-2/h5-9H,3-4H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tamkang University Curated by ChEMBL					Assay Description Inhibitory activity against 15-lipoxygenase was determined obtained from soya bean				Bioorg Med Chem Lett 14: 63-5 (2003) BindingDB Entry DOI: 10.7270/Q2PC31TX
					More data for this Ligand-Target Pair