BDBM50137569 3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}-propionamide::CHEMBL301271

SMILES: CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1

InChI Key: InChIKey=YAAKXNXVUNFSPT-ATVHPVEESA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50137569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Fyn tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Fibroblast growth factor receptor 1				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assay				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Vascular endothelial growth factor receptor 2				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Src protein tryrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50137569 (3-{2-[5-Ethanesulfonyl-2-oxo-1,2-dihydro-indol-(3Z...) Show SMILES CCS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCC(N)=O)c2c1 Show InChI InChI=1S/C22H25N3O4S/c1-2-30(28,29)13-7-9-19-16(11-13)17(22(27)25-19)12-20-15(8-10-21(23)26)14-5-3-4-6-18(14)24-20/h7,9,11-12,24H,2-6,8,10H2,1H3,(H2,23,26)(H,25,27)/b17-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Yes tyrosine kinase				Bioorg Med Chem Lett 14: 187-90 (2003) BindingDB Entry DOI: 10.7270/Q2HM57VG
					More data for this Ligand-Target Pair