BDBM50137830 6-(5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hexanoic acid (2-amino-phenyl)-amide::CHEMBL314301
SMILES: Nc1ccccc1NC(=O)CCCCCN1C(=O)c2ccc(O)cc2C1=O
InChI Key: InChIKey=WMHFSCVKPHKILO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50137830 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50137830
(6-(5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-...)Show InChI InChI=1S/C20H21N3O4/c21-16-6-3-4-7-17(16)22-18(25)8-2-1-5-11-23-19(26)14-10-9-13(24)12-15(14)20(23)27/h3-4,6-7,9-10,12,24H,1-2,5,8,11,21H2,(H,22,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description Effect on induced hyperacetylation of histones in whole cells |
Bioorg Med Chem Lett 14: 283-7 (2003)
BindingDB Entry DOI: 10.7270/Q2BV7G17 |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50137830
(6-(5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-...)Show InChI InChI=1S/C20H21N3O4/c21-16-6-3-4-7-17(16)22-18(25)8-2-1-5-11-23-19(26)14-10-9-13(24)12-15(14)20(23)27/h3-4,6-7,9-10,12,24H,1-2,5,8,11,21H2,(H,22,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description Ability to inhibit recombinant human histone deacetylase 1 (HDAC-1). |
Bioorg Med Chem Lett 14: 283-7 (2003)
BindingDB Entry DOI: 10.7270/Q2BV7G17 |
More data for this Ligand-Target Pair | |