BDBM50137854 (Z)-4-[3-(3,5-Dichloro-2-cyano-benzyloxy)-phenyl]-2-hydroxy-4-oxo-but-2-enoic acid::CHEMBL174719

SMILES: OC(=O)C(=O)CC(=O)c1cccc(OCc2cc(Cl)cc(Cl)c2C#N)c1

InChI Key: InChIKey=NLBOGEWZWDRQOT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50137854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50137854 ((Z)-4-[3-(3,5-Dichloro-2-cyano-benzyloxy)-phenyl]-...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2cc(Cl)cc(Cl)c2C#N)c1 Show InChI InChI=1S/C18H11Cl2NO5/c19-12-4-11(14(8-21)15(20)6-12)9-26-13-3-1-2-10(5-13)16(22)7-17(23)18(24)25/h1-6H,7,9H2,(H,24,25)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory activity of the compound against HIV-1 reverse transcriptase was determined				J Med Chem 47: 14-7 (2003) Article DOI: 10.1021/jm0342109 BindingDB Entry DOI: 10.7270/Q2736QB8
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50137854 ((Z)-4-[3-(3,5-Dichloro-2-cyano-benzyloxy)-phenyl]-...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2cc(Cl)cc(Cl)c2C#N)c1 Show InChI InChI=1S/C18H11Cl2NO5/c19-12-4-11(14(8-21)15(20)6-12)9-26-13-3-1-2-10(5-13)16(22)7-17(23)18(24)25/h1-6H,7,9H2,(H,24,25)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B				J Med Chem 47: 14-7 (2003) Article DOI: 10.1021/jm0342109 BindingDB Entry DOI: 10.7270/Q2736QB8
					More data for this Ligand-Target Pair