BindingDB PrimarySearch

BDBM50138662 6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-aminomethyl-phenyl)-amide::6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE::CHEMBL324168::N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide::uPa_9

SMILES: NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1

InChI Key: InChIKey=NLBDETRVUYOIHQ-UHFFFAOYSA-N

Data: 13 KI 4 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50138662
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB D3R	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
D3R					Assay Description Photometric_Method1				D3R 227: (2015) BindingDB Entry DOI: 10.7270/Q24B305P
D3R					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity to human urokinase-type plasminogen activator (microPa).				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of urokinase				J Med Chem 52: 3159-65 (2009) Article DOI: 10.1021/jm801444x BindingDB Entry DOI: 10.7270/Q2FF3TM8
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	40	-10.1	n/a	n/a	n/a	n/a	n/a	7.4	25
CSAR					Assay Description Abbott uPA__Urokinase Human - Ki(uM)				CSAR 1: (2012)
CSAR					More data for this Ligand-Target Pair				3D Structure (crystal)
Trypsin-1 (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against porcine trypsin was determined.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.17E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against human plasma kallikrein.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human plasmin.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human Tissue type plasminogen activator.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against human alpha thrombin.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Plasminogen (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50138662 (6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...				Bioorg Med Chem 20: 1557-68 (2012) Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair