BDBM50138663 2-naphthimidamide::CHEMBL105171::Naphthalene-2-carboxamidine::uPa_6

SMILES: NC(=N)c1ccc2ccccc2c1

InChI Key: InChIKey=URXJHZXEUUFNKM-UHFFFAOYSA-N

Data: 13 KI

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50138663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Urokinase-type plasminogen activator (urokinase)				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB D3R	5.91E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
D3R					Assay Description Photometric_Method1				D3R 227: (2015) BindingDB Entry DOI: 10.7270/Q24B305P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	5.91E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity to human urokinase-type plasminogen activator (microPa).				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	5.91E+3	-7.13	n/a	n/a	n/a	n/a	n/a	7.4	25
CSAR					Assay Description Abbott uPA__Urokinase Human - Ki(uM)				CSAR 1: (2012)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	6.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of urokinase				J Med Chem 52: 3159-65 (2009) Article DOI: 10.1021/jm801444x BindingDB Entry DOI: 10.7270/Q2FF3TM8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Trypsin-1 (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	7.78E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against porcine trypsin was determined.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against trypsin				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	2.25E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against human plasma kallikrein.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
					More data for this Ligand-Target Pair
Kallikrein 1 (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards P-kallikrein				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against plasmin				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	5.13E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human plasmin.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards tissue type plasminogen activator				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair				3D Structure (docked)
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50138663 (2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...) Show SMILES NC(=N)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human Tissue type plasminogen activator.				J Med Chem 47: 303-24 (2004) Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH
					More data for this Ligand-Target Pair				3D Structure (docked)